Correlation of AP-2α with trophoblast apoptosis and invasion in placental tissues of preeclampsia

• Main Authors: Ping Zhou, Xue-Mei Gao, Han Wang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-12-01
• Series: Journal of Hainan Medical University
• Subjects: Preeclampsia; AP-2α; Apoptosis; Invasion; Article History
• Online Access: http://www.hnykdxxb.com/PDF/201812/08.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To investigate the correlation of AP-2α with trophoblast apoptosis and invasion in placental tissues of preeclampsia. Methods: A total of 68 puerperae with preeclampsia who gave birth in our hospital between November 2015 and October 2017 were selected as preeclampsia group, and 60 healthy puerperae who gave birth in our hospital during the same period were selected as normal control group. The differences in expression of AP-2α gene, apoptosis-related genes and invasion-related genes in placenta tissue were compared between the two groups, and the inner link of AP-2α gene expression with trophoblast apoptosis and invasion activity in placental tissues of preeclampsia was further analyzed. Results: AP-2α mRNA expression in placental tissue of preeclampsia group was higher than that of control group; apoptosis-related genes Bcl and Cx43 mRNA expression were lower than those of control group whereas Bax, Caspase7 and metastin mRNA expression were higher than those of control group; invasion-related genes HIF-1α, GPR30, MEST and Snail mRNA expression were lower than those of control group whereas PEDF and RECK mRNA expression were higher than those of control group. Pearson test showed that the AP-2α gene expression in the placental tissues of preeclampsia was directly correlated with the expression of trophoblast apoptosis-related genes and invasion-related genes. Conclusion: AP-2α gene expression significantly increases in the placental tissue of puerperae with preeclampsia, and it can positively regulate the trophoblast apoptosis activity and negatively regulate its invasion activity.