Early multifocal electroretinography findings after intravitreal Conbercept in the treatment of wet age-related macular degeneration

• Main Authors: Ding-Guo Huang, Jian-Long Zheng, Guo-Qiao Lin, Wei-Qi Chen
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2018-09-01
• Series: Guoji Yanke Zazhi
• Subjects: multifocal electroretinography; conbercept; wet age-related macular degeneration
• Online Access: http://ies.ijo.cn/cn_publish/2018/9/201809031.pdf

AIM: To evaluate the early changes of retinal function in patients with wet age-related macular degeneration(ARMD)after intravitreal Conbercept treatment by multifocal electroretinography(mfERG). <p>METHODS: Wet ARMD patients diagnosed by fundus fluorescein angiography and received intravitreal injection of Conbercept(0.05mL/0.5mg)were included. Best corrected visual acuity(BCVA), incubation of N1, P1 and amplitude of P1 in mfERG test were recorded before and 1mo after treatment. <p>RESULTS: Twenty patients(20 eyes)were enrolled in total. The mean BCVA was 0.80±0.48 LogMAR at baseline and improved to 0.65±0.50 LogMAR after treatment(<i>P</i><0.001). Mean P1 amplitude density of the mfERG Ring 1 increased from 39.59±16.60nV/deg² to 53.81±20.41nV/deg²(<i>P</i>=0.006). The change in visual acuity was positively correlated with the change in P1 amplitude density of Ring 1(<i>r</i>=-0.776, <i>P</i><0.001). <p>CONCLUSION: Intravitreal conbercept injection can improve the central retinal function of wet ARMD patients in the short term.