Characterization of a Novel BmαTX47 Toxin Modulating Sodium Channels: The Crucial Role of Expression Vectors in Toxin Pharmacological Activity

Characterization of a Novel BmαTX47 Toxin Modulating Sodium Channels: The Crucial Role of Expression Vectors in Toxin Pharmacological Activity

Long-chain scorpion toxins with four disulfide bridges exhibit various pharmacological features towards the different voltage-gated sodium channel subtypes. However, the toxin production still remains a huge challenge. Here, we reported the effects of different expression vectors on the pharmacologi...

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Bibliographic Details
Main Authors: Tian Li, Lingna Xu, Honglian Liu, Yawen He, Songping Liang, Wenxin Li, Yingliang Wu
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Toxins
Subjects:
Buthus martensii Karsch
BmαTX47
recombinant expression
sodium channels
pET-28a vector
pET-14b vector
Online Access:http://www.mdpi.com/2072-6651/6/3/816

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