FHR4‐based immunoconjugates direct complement‐dependent cytotoxicity and phagocytosis towards HER2‐positive cancer cells

FHR4‐based immunoconjugates direct complement‐dependent cytotoxicity and phagocytosis towards HER2‐positive cancer cells

Directing selective complement activation towards tumour cells is an attractive strategy to promote their elimination. In the present work, we have generated heteromultimeric immunoconjugates that selectively activate the complement alternative pathway (AP) on tumour cells. We used the C4b‐binding p...

Full description

Bibliographic Details
Main Authors: Carole Seguin‐Devaux, Jean‐Marc Plesseria, Charlène Verschueren, Cécile Masquelier, Gilles Iserentant, Marie Fullana, Mihály Józsi, Jacques H. M. Cohen, Xavier Dervillez
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Molecular Oncology
Subjects:
C4bp
CDC
complement resistance
FHR4
MAC
multimers
Online Access:https://doi.org/10.1002/1878-0261.12554

Internet

https://doi.org/10.1002/1878-0261.12554

Similar Items