The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved]

An interesting and valuable discussion has arisen from our recent article (Segerdahl, Mezue et al., 2015) and we are pleased here to have the opportunity to expand on the various points we made. Equally important, we wish to correct several important misunderstandings that were made by Davis and col...

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Main Authors:	Andrew R. Segerdahl, Melvin Mezue, Thomas W. Okell, John T. Farrar, Irene Tracey
Format:	Article
Language:	English
Published:	F1000 Research Ltd 2015-11-01
Series:	F1000Research
Subjects:	Pain: Basic Science
Online Access:	http://f1000research.com/articles/4-1207/v1

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record_format	Article
spelling	doaj-84be82b9407541daa7efad4509a85b122020-11-25T03:50:03ZengF1000 Research LtdF1000Research2046-14022015-11-01410.12688/f1000research.7287.17854The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved]Andrew R. Segerdahl0Melvin Mezue1Thomas W. Okell2John T. Farrar3Irene Tracey4Nuffield Division of Anesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 4BH, UKNuffield Division of Anesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 4BH, UKOxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 4BH, UKCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104-6291, USANuffield Division of Anesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 4BH, UKAn interesting and valuable discussion has arisen from our recent article (Segerdahl, Mezue et al., 2015) and we are pleased here to have the opportunity to expand on the various points we made. Equally important, we wish to correct several important misunderstandings that were made by Davis and colleagues that possibly contributed to their concerns about power when assessing our paper (e.g. actual subject numbers used in control experiment and the reality of the signal-to-noise and sampling of the multi-TI technique we employed). Here, we clarify the methods and analysis plus discuss how we interpret the data in the Brief Communication noting that the extrapolation and inferences made by Davis and colleagues are not consistent with our report or necessarily, in our opinion, what the data supports. We trust this reassures the F1000Research readership regarding the robustness of our results and what we actually concluded in the paper regarding their possible meaning. We are pleased, though, that Davis and colleagues have used our article to raise an important discussion around pain perception, and here offer some further insights towards that broader discussion.http://f1000research.com/articles/4-1207/v1Pain: Basic Science
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andrew R. Segerdahl Melvin Mezue Thomas W. Okell John T. Farrar Irene Tracey
spellingShingle	Andrew R. Segerdahl Melvin Mezue Thomas W. Okell John T. Farrar Irene Tracey The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved] F1000Research Pain: Basic Science
author_facet	Andrew R. Segerdahl Melvin Mezue Thomas W. Okell John T. Farrar Irene Tracey
author_sort	Andrew R. Segerdahl
title	The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved]
title_short	The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved]
title_full	The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved]
title_fullStr	The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved]
title_full_unstemmed	The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved]
title_sort	dorsal posterior insula is not an island in pain but subserves a fundamental role - response to: “evidence against pain specificity in the dorsal posterior insula” by davis et al. [version 1; referees: 2 approved]
publisher	F1000 Research Ltd
series	F1000Research
issn	2046-1402
publishDate	2015-11-01
description	An interesting and valuable discussion has arisen from our recent article (Segerdahl, Mezue et al., 2015) and we are pleased here to have the opportunity to expand on the various points we made. Equally important, we wish to correct several important misunderstandings that were made by Davis and colleagues that possibly contributed to their concerns about power when assessing our paper (e.g. actual subject numbers used in control experiment and the reality of the signal-to-noise and sampling of the multi-TI technique we employed). Here, we clarify the methods and analysis plus discuss how we interpret the data in the Brief Communication noting that the extrapolation and inferences made by Davis and colleagues are not consistent with our report or necessarily, in our opinion, what the data supports. We trust this reassures the F1000Research readership regarding the robustness of our results and what we actually concluded in the paper regarding their possible meaning. We are pleased, though, that Davis and colleagues have used our article to raise an important discussion around pain perception, and here offer some further insights towards that broader discussion.
topic	Pain: Basic Science
url	http://f1000research.com/articles/4-1207/v1
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The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al. [version 1; referees: 2 approved]

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