Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations
Chitosan aerogels with potential applications as effective local hemostatic agents were prepared using supercritical carbon dioxide drying to preserve the chitosan network structure featuring high internal surfaces and porosities of up to 300 m²/g and 98%, respectively. For the first time, hemostati...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/12/9/2055 |
| id |
doaj-84b6bb79ed3d4bb9b562ebcb88471ea7 |
|---|---|
| record_format |
Article |
| spelling |
doaj-84b6bb79ed3d4bb9b562ebcb88471ea72020-11-25T02:52:41ZengMDPI AGPolymers2073-43602020-09-01122055205510.3390/polym12092055Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo EvaluationsDaria Lovskaya0Natalia Menshutina1Maria Mochalova2Artem Nosov3Alexander Grebenyuk4International Center for transfer of Pharmaceutical and Biotechnology, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, RussiaInternational Center for transfer of Pharmaceutical and Biotechnology, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, RussiaInternational Center for transfer of Pharmaceutical and Biotechnology, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, RussiaDepartment of Pharmaceutical Chemistry, Saint Petersburg State Chemical Pharmaceutical University, 197376 Saint Petersburg, RussiaDepartment of Pharmaceutical Chemistry, Saint Petersburg State Chemical Pharmaceutical University, 197376 Saint Petersburg, RussiaChitosan aerogels with potential applications as effective local hemostatic agents were prepared using supercritical carbon dioxide drying to preserve the chitosan network structure featuring high internal surfaces and porosities of up to 300 m²/g and 98%, respectively. For the first time, hemostatic efficacy of chitosan-based aerogel particles was studied in vivo on a model of damage of a large vessel in the deep wound. Pigs were used as test animals. It was shown that primary hemostasis was achieved, there were no signs of rebleeding and aerogel particles were tightly fixed to the walls of the wound canal. A dense clot was formed inside the wound (at the femoral artery), which indicates stable hemostasis. This study demonstrated that chitosan-based aerogel particles have a high sorption capacity and are highly effective as local hemostatic agents which can be used to stop massive bleeding.https://www.mdpi.com/2073-4360/12/9/2055aerogelschitosanblood sorptionin vivo evaluationslocal hemostatic agent |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Daria Lovskaya Natalia Menshutina Maria Mochalova Artem Nosov Alexander Grebenyuk |
| spellingShingle |
Daria Lovskaya Natalia Menshutina Maria Mochalova Artem Nosov Alexander Grebenyuk Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations Polymers aerogels chitosan blood sorption in vivo evaluations local hemostatic agent |
| author_facet |
Daria Lovskaya Natalia Menshutina Maria Mochalova Artem Nosov Alexander Grebenyuk |
| author_sort |
Daria Lovskaya |
| title |
Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations |
| title_short |
Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations |
| title_full |
Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations |
| title_fullStr |
Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations |
| title_full_unstemmed |
Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations |
| title_sort |
chitosan-based aerogel particles as highly effective local hemostatic agents. production process and in vivo evaluations |
| publisher |
MDPI AG |
| series |
Polymers |
| issn |
2073-4360 |
| publishDate |
2020-09-01 |
| description |
Chitosan aerogels with potential applications as effective local hemostatic agents were prepared using supercritical carbon dioxide drying to preserve the chitosan network structure featuring high internal surfaces and porosities of up to 300 m²/g and 98%, respectively. For the first time, hemostatic efficacy of chitosan-based aerogel particles was studied in vivo on a model of damage of a large vessel in the deep wound. Pigs were used as test animals. It was shown that primary hemostasis was achieved, there were no signs of rebleeding and aerogel particles were tightly fixed to the walls of the wound canal. A dense clot was formed inside the wound (at the femoral artery), which indicates stable hemostasis. This study demonstrated that chitosan-based aerogel particles have a high sorption capacity and are highly effective as local hemostatic agents which can be used to stop massive bleeding. |
| topic |
aerogels chitosan blood sorption in vivo evaluations local hemostatic agent |
| url |
https://www.mdpi.com/2073-4360/12/9/2055 |
| work_keys_str_mv |
AT darialovskaya chitosanbasedaerogelparticlesashighlyeffectivelocalhemostaticagentsproductionprocessandinvivoevaluations AT nataliamenshutina chitosanbasedaerogelparticlesashighlyeffectivelocalhemostaticagentsproductionprocessandinvivoevaluations AT mariamochalova chitosanbasedaerogelparticlesashighlyeffectivelocalhemostaticagentsproductionprocessandinvivoevaluations AT artemnosov chitosanbasedaerogelparticlesashighlyeffectivelocalhemostaticagentsproductionprocessandinvivoevaluations AT alexandergrebenyuk chitosanbasedaerogelparticlesashighlyeffectivelocalhemostaticagentsproductionprocessandinvivoevaluations |
| _version_ |
1724728345940197376 |