RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS

RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS

Male Wistar rats, pretreated with desipramine (25 mg/kg b.w., i.p., Sigma), 30 minutes before the 6-hydroxydopamine infusion to protect noradrenergic projections, were used. Specific lesions of the dopaminergic neurons located in substantia nigra pars reticulata were produced with 6-hydroxydopamine...

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Main Authors: Lucian Hritcu, Calin Maniu, Cristian Campeanu
Format: Article
Language:English
Published: "Alexandru Ioan Cuza" University of Iași 2007-08-01
Series:Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
Online Access:http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/397
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spelling doaj-84b32f2600124d04914a3e9ba731835b2020-11-24T22:31:04Zeng"Alexandru Ioan Cuza" University of IașiAnalele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara 1582-35712007-08-0181RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATSLucian HritcuCalin ManiuCristian CampeanuMale Wistar rats, pretreated with desipramine (25 mg/kg b.w., i.p., Sigma), 30 minutes before the 6-hydroxydopamine infusion to protect noradrenergic projections, were used. Specific lesions of the dopaminergic neurons located in substantia nigra pars reticulata were produced with 6-hydroxydopamine (6-OHDA) (8μg/4μl i.c.v., Sigma), a noradrenergic-selective neurotoxin. We assessed the hematological parameters (the total number of erythrocyte, hematocrit and hemoglobin), 1 week after the neurosurgery. Briefly, we observed that electrolytic lesion of substantia nigra induce sever abnormalities of hematopoesis regulationhttp://www.gbm.bio.uaic.ro/index.php/gbm/article/view/397
collection DOAJ
language English
format Article
sources DOAJ
author Lucian Hritcu
Calin Maniu
Cristian Campeanu
spellingShingle Lucian Hritcu
Calin Maniu
Cristian Campeanu
RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS
Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
author_facet Lucian Hritcu
Calin Maniu
Cristian Campeanu
author_sort Lucian Hritcu
title RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS
title_short RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS
title_full RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS
title_fullStr RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS
title_full_unstemmed RIGHT-UNILATERAL LESION OF SUBSTANTIA NIGRA-INDUCE CHANGES OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS
title_sort right-unilateral lesion of substantia nigra-induce changes of hematological parameters in wistar rats
publisher "Alexandru Ioan Cuza" University of Iași
series Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
issn 1582-3571
publishDate 2007-08-01
description Male Wistar rats, pretreated with desipramine (25 mg/kg b.w., i.p., Sigma), 30 minutes before the 6-hydroxydopamine infusion to protect noradrenergic projections, were used. Specific lesions of the dopaminergic neurons located in substantia nigra pars reticulata were produced with 6-hydroxydopamine (6-OHDA) (8μg/4μl i.c.v., Sigma), a noradrenergic-selective neurotoxin. We assessed the hematological parameters (the total number of erythrocyte, hematocrit and hemoglobin), 1 week after the neurosurgery. Briefly, we observed that electrolytic lesion of substantia nigra induce sever abnormalities of hematopoesis regulation
url http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/397
work_keys_str_mv AT lucianhritcu rightunilaterallesionofsubstantianigrainducechangesofhematologicalparametersinwistarrats
AT calinmaniu rightunilaterallesionofsubstantianigrainducechangesofhematologicalparametersinwistarrats
AT cristiancampeanu rightunilaterallesionofsubstantianigrainducechangesofhematologicalparametersinwistarrats
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