Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages

Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages

Inflammation is the hallmark of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli-induced bovine mastitis. Organic selenium can activate pivotal proteins in immune responses and regulate the immune system. The present study aimed to investigate whether selenomethionine (SeMet) attenuat...

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Bibliographic Details
Main Authors: Cuicui Zhuang, Gang Liu, Herman W. Barkema, Man Zhou, Siyu Xu, Sadeeq ur Rahman, Yongxia Liu, John P. Kastelic, Jian Gao, Bo Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Microbiology
Subjects:
selenomethionine
ESBL-Escherichia coli
bovine mastitis
inflammation
selenoprotein S
TLR4/NF-κB pathway
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01461/full

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