Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles

Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles

In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram-negative and...

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Main Authors: Bahram Letafat, Negar Mohammadhosseini, Ali Asadipour, Alireza Foroumadi
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2011/642071
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spelling doaj-84a13e11299c4b2fb2edb08c767abbb62020-11-25T01:00:40ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102011-01-01831120112310.1155/2011/642071Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazolesBahram Letafat0Negar Mohammadhosseini1Ali Asadipour2Alireza Foroumadi3Department of Chemistry, Islamshahr Branch, Islamic Azad University, Tehran, IranDepartment of Chemistry, Islamshahr Branch, Islamic Azad University, Tehran, IranDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, IranDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, IranIn the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram-negative and gram-positive bacteria. Compound 6b with 5-(5-nitrofuran-2-yl)-residue on 1,3,4-thiadiazole scaffold have shown promising antibacterial activities against gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis.http://dx.doi.org/10.1155/2011/642071
collection DOAJ
language English
format Article
sources DOAJ
author Bahram Letafat
Negar Mohammadhosseini
Ali Asadipour
Alireza Foroumadi
spellingShingle Bahram Letafat
Negar Mohammadhosseini
Ali Asadipour
Alireza Foroumadi
Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
E-Journal of Chemistry
author_facet Bahram Letafat
Negar Mohammadhosseini
Ali Asadipour
Alireza Foroumadi
author_sort Bahram Letafat
title Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
title_short Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
title_full Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
title_fullStr Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
title_full_unstemmed Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
title_sort synthesis and in vitro antibacterial activity of new 2-(1-methyl-4-nitro-1h-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2011-01-01
description In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram-negative and gram-positive bacteria. Compound 6b with 5-(5-nitrofuran-2-yl)-residue on 1,3,4-thiadiazole scaffold have shown promising antibacterial activities against gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis.
url http://dx.doi.org/10.1155/2011/642071
work_keys_str_mv AT bahramletafat synthesisandinvitroantibacterialactivityofnew21methyl4nitro1himidazol5ylsulfonyl134thiadiazoles
AT negarmohammadhosseini synthesisandinvitroantibacterialactivityofnew21methyl4nitro1himidazol5ylsulfonyl134thiadiazoles
AT aliasadipour synthesisandinvitroantibacterialactivityofnew21methyl4nitro1himidazol5ylsulfonyl134thiadiazoles
AT alirezaforoumadi synthesisandinvitroantibacterialactivityofnew21methyl4nitro1himidazol5ylsulfonyl134thiadiazoles
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