A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

Dysfunctional and disfiguring scars can result from aberrant wound repair. Here, the authors develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for scarless w...

Full description

Bibliographic Details
Main Authors: Jian Zhang, Yongjun Zheng, Jimmy Lee, Jieyu Hua, Shilong Li, Ananth Panchamukhi, Jiping Yue, Xuewen Gou, Zhaofan Xia, Linyong Zhu, Xiaoyang Wu
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21964-0
id doaj-849f5fb7a026401fac2fcd2cc68603a8
record_format Article
spelling doaj-849f5fb7a026401fac2fcd2cc68603a82021-03-21T12:13:13ZengNature Publishing GroupNature Communications2041-17232021-03-0112111310.1038/s41467-021-21964-0A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healingJian Zhang0Yongjun Zheng1Jimmy Lee2Jieyu Hua3Shilong Li4Ananth Panchamukhi5Jiping Yue6Xuewen Gou7Zhaofan Xia8Linyong Zhu9Xiaoyang Wu10The University of Chicago, Ben May Department for Cancer ResearchKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & TechnologyThe University of Chicago, Ben May Department for Cancer ResearchKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & TechnologyThe University of Chicago, Ben May Department for Cancer ResearchThe University of Chicago, Ben May Department for Cancer ResearchThe University of Chicago, Ben May Department for Cancer ResearchThe University of Chicago, Ben May Department for Cancer ResearchBurns Center of Changhai HospitalKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & TechnologyThe University of Chicago, Ben May Department for Cancer ResearchDysfunctional and disfiguring scars can result from aberrant wound repair. Here, the authors develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for scarless wound repair.https://doi.org/10.1038/s41467-021-21964-0
collection DOAJ
language English
format Article
sources DOAJ
author Jian Zhang
Yongjun Zheng
Jimmy Lee
Jieyu Hua
Shilong Li
Ananth Panchamukhi
Jiping Yue
Xuewen Gou
Zhaofan Xia
Linyong Zhu
Xiaoyang Wu
spellingShingle Jian Zhang
Yongjun Zheng
Jimmy Lee
Jieyu Hua
Shilong Li
Ananth Panchamukhi
Jiping Yue
Xuewen Gou
Zhaofan Xia
Linyong Zhu
Xiaoyang Wu
A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
Nature Communications
author_facet Jian Zhang
Yongjun Zheng
Jimmy Lee
Jieyu Hua
Shilong Li
Ananth Panchamukhi
Jiping Yue
Xuewen Gou
Zhaofan Xia
Linyong Zhu
Xiaoyang Wu
author_sort Jian Zhang
title A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
title_short A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
title_full A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
title_fullStr A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
title_full_unstemmed A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
title_sort pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description Dysfunctional and disfiguring scars can result from aberrant wound repair. Here, the authors develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for scarless wound repair.
url https://doi.org/10.1038/s41467-021-21964-0
work_keys_str_mv AT jianzhang apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT yongjunzheng apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT jimmylee apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT jieyuhua apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT shilongli apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT ananthpanchamukhi apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT jipingyue apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT xuewengou apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT zhaofanxia apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT linyongzhu apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT xiaoyangwu apulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT jianzhang pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT yongjunzheng pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT jimmylee pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT jieyuhua pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT shilongli pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT ananthpanchamukhi pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT jipingyue pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT xuewengou pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT zhaofanxia pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT linyongzhu pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
AT xiaoyangwu pulsatilereleaseplatformbasedonphotoinducediminecrosslinkinghydrogelpromotesscarlesswoundhealing
_version_ 1724210760457912320

Similar Items