Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis

Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) is among the most common and devastating diseases in neonates and, despite the significant advances in neonatal clinical and basic science investigations, its etiology is largely understood, specific treatment strategies are lacking, and morbidity and mortality remain...

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Main Authors: Gianluca Terrin, Antonella Scipione, Mario De Curtis
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/543765
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spelling doaj-849e970e49684ccbaef20af6465461472020-11-24T23:18:40ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/543765543765Update in Pathogenesis and Prospective in Treatment of Necrotizing EnterocolitisGianluca Terrin0Antonella Scipione1Mario De Curtis2Department of Perinatal Medicine, Sapienza University, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Pediatrics and Infant’s Neuropsychiatry, University of Rome “La Sapienza”, Rome, ItalyDepartment of Pediatrics and Infant’s Neuropsychiatry, University of Rome “La Sapienza”, Rome, ItalyNecrotizing enterocolitis (NEC) is among the most common and devastating diseases in neonates and, despite the significant advances in neonatal clinical and basic science investigations, its etiology is largely understood, specific treatment strategies are lacking, and morbidity and mortality remain high. Improvements in the understanding of pathogenesis of NEC may have therapeutic consequences. Pharmacologic inhibition of toll-like receptor signaling, the use of novel nutritional strategies, and microflora modulation may represent novel promising approaches to the prevention and treatment of NEC. This review, starting from the recent acquisitions in the pathogenic mechanisms of NEC, focuses on current and possible therapeutic perspectives.http://dx.doi.org/10.1155/2014/543765
collection DOAJ
language English
format Article
sources DOAJ
author Gianluca Terrin
Antonella Scipione
Mario De Curtis
spellingShingle Gianluca Terrin
Antonella Scipione
Mario De Curtis
Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis
BioMed Research International
author_facet Gianluca Terrin
Antonella Scipione
Mario De Curtis
author_sort Gianluca Terrin
title Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis
title_short Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis
title_full Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis
title_fullStr Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis
title_full_unstemmed Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis
title_sort update in pathogenesis and prospective in treatment of necrotizing enterocolitis
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description Necrotizing enterocolitis (NEC) is among the most common and devastating diseases in neonates and, despite the significant advances in neonatal clinical and basic science investigations, its etiology is largely understood, specific treatment strategies are lacking, and morbidity and mortality remain high. Improvements in the understanding of pathogenesis of NEC may have therapeutic consequences. Pharmacologic inhibition of toll-like receptor signaling, the use of novel nutritional strategies, and microflora modulation may represent novel promising approaches to the prevention and treatment of NEC. This review, starting from the recent acquisitions in the pathogenic mechanisms of NEC, focuses on current and possible therapeutic perspectives.
url http://dx.doi.org/10.1155/2014/543765
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AT antonellascipione updateinpathogenesisandprospectiveintreatmentofnecrotizingenterocolitis
AT mariodecurtis updateinpathogenesisandprospectiveintreatmentofnecrotizingenterocolitis
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