Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis Through miR-3546/SOX4/Survivin Axis in Rat Thy-1 Nephritis

Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis Through miR-3546/SOX4/Survivin Axis in Rat Thy-1 Nephritis

Background/Aims: The activation of complement system and the formation of C5b-9 complex have been confirmed in the glomeruli of patients with mesangioproliferative glomerulonephritis (MsPGN). However, the role and mechanism of C5b-9-induced injury in glomerular mesangial cell (GMC) are poorly unders...

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Main Authors: Chunyan Yao, Fengxia He, Longfei Liu, Zhiwei Zhang, Chenhui Zhao, Wen Qiu, Dan Zhao, Jing Zhang, Mengxiao Xie, Yajuan Gong, Tianyi Yu, Lu Xia, Baomei Qian, Yingwei Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Thy-1 Nephritis
Sublytic C5b-9
Glomerular mesangial cells
Apoptosis
miR-3546
SOX4
Survivin
Online Access:https://www.karger.com/Article/FullText/493652

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