Variants of the human RAD52 gene confer defects in ionizing radiation resistance and homologous recombination repair in budding yeast

Variants of the human RAD52 gene confer defects in ionizing radiation resistance and homologous recombination repair in budding yeast

RAD52 is a structurally and functionally conserved component of the DNA double-strand break (DSB) repair apparatus from budding yeast to humans. We recently showed that expressing the human gene, HsRAD52 in rad52 mutant budding yeast cells can suppress both their ionizing radiation (IR) sensitivity...

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Bibliographic Details
Main Authors: Alissa D. Clear, Glenn M. Manthey, Olivia Lewis, Isabelle Y. Lopez, Rossana Rico, Shannon Owens, M. Cristina Negritto, Elise W. Wolf, Jason Xu, Nikola Kenjić, J. Jefferson P. Perry, Aaron W. Adamson, Susan L. Neuhausen, Adam M. Bailis
Format: Article
Language:English
Published: Shared Science Publishers OG 2020-07-01
Series:Microbial Cell
Subjects:
hsrad52 variants
tumorigenesis
dna double strand breaks
homologous recombination repair
ionizing radiation
budding yeast
Online Access:http://microbialcell.com/researcharticles/2020a-clear-microbial-cell/

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