Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study

Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study

For the manufacturing of complex biopharmaceuticals using bioreactors with cultivated mammalian cells, high product concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favor...

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Bibliographic Details
Main Authors: Tanja Hernández Rodríguez, Sophie Morerod, Ralf Pörtner, Florian M. Wurm, Björn Frahm
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Processes
Subjects:
clonal cell population
phenotypic diversity
inoculum train
uncertainty-based
cell culture model
biopharmaceutical manufacturing
Online Access:https://www.mdpi.com/2227-9717/9/6/964

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