A high throughput screening assay system for the identification of small molecule inhibitors of gsp.

A high throughput screening assay system for the identification of small molecule inhibitors of gsp.

Mis-sense mutations in the α-subunit of the G-protein, Gsα, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active Gsα and increased levels of cAMP. The aim of this study was to develop an assay system that would allow the identi...

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Bibliographic Details
Main Authors: Nisan Bhattacharyya, Xin Hu, Catherine Z Chen, Lesley A Mathews Griner, Wei Zheng, James Inglese, Christopher P Austin, Juan J Marugan, Noel Southall, Susanne Neumann, John K Northup, Marc Ferrer, Michael T Collins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3965391?pdf=render

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http://europepmc.org/articles/PMC3965391?pdf=render

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