VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome

VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome

Abstract Background There is an urgent need for objective markers of Alzheimer’s disease (AD)-related cognitive impairment in people with Down syndrome (DS) to improve diagnosis, monitor disease progression, and assess response to disease-modifying therapies. Previously, GluA4 and neuronal pentraxin...

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Bibliographic Details
Main Authors: Alberto Lleó, Maria Carmona-Iragui, Laura Videla, Susana Fernández, Bessy Benejam, Jordi Pegueroles, Isabel Barroeta, Miren Altuna, Silvia Valldeneu, Mei-Fang Xiao, Desheng Xu, Raúl Núñez-Llaves, Marta Querol-Vilaseca, Sònia Sirisi, Alexandre Bejanin, M. Florencia Iulita, Jordi Clarimón, Rafael Blesa, Paul Worley, Daniel Alcolea, Juan Fortea, Olivia Belbin
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Down syndrome
Alzheimer’s disease
Synapse
Biomarker
Cognitive decline
Online Access:https://doi.org/10.1186/s13195-021-00861-0

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