Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development

By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating a...

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Main Authors:	Rebecca L. Cunningham, Eva T. Kramer, Sophia K. DeGeorgia, Paula M. Godoy, Anna P. Zarov, Shayana Seneviratne, Vadim Grigura, Charles K. Kaufman
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02211-0

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spelling	doaj-847afc3cf583438186c5a7ab690ba4a32021-06-13T11:33:53ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111510.1038/s42003-021-02211-0Functional in vivo characterization of sox10 enhancers in neural crest and melanoma developmentRebecca L. Cunningham0Eva T. Kramer1Sophia K. DeGeorgia2Paula M. Godoy3Anna P. Zarov4Shayana Seneviratne5Vadim Grigura6Charles K. Kaufman7Division of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint LouisDivision of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint LouisDivision of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint LouisDivision of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint LouisDivision of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint LouisSchool of Arts and Sciences, Washington University in Saint LouisDivision of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint LouisDivision of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint LouisBy performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating an enhancer function for peak5 and provide insights into neural crest development and melanoma initiation.https://doi.org/10.1038/s42003-021-02211-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rebecca L. Cunningham Eva T. Kramer Sophia K. DeGeorgia Paula M. Godoy Anna P. Zarov Shayana Seneviratne Vadim Grigura Charles K. Kaufman
spellingShingle	Rebecca L. Cunningham Eva T. Kramer Sophia K. DeGeorgia Paula M. Godoy Anna P. Zarov Shayana Seneviratne Vadim Grigura Charles K. Kaufman Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development Communications Biology
author_facet	Rebecca L. Cunningham Eva T. Kramer Sophia K. DeGeorgia Paula M. Godoy Anna P. Zarov Shayana Seneviratne Vadim Grigura Charles K. Kaufman
author_sort	Rebecca L. Cunningham
title	Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_short	Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_full	Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_fullStr	Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_full_unstemmed	Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
title_sort	functional in vivo characterization of sox10 enhancers in neural crest and melanoma development
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-06-01
description	By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating an enhancer function for peak5 and provide insights into neural crest development and melanoma initiation.
url	https://doi.org/10.1038/s42003-021-02211-0
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Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development

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