Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.

To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model wa...

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Main Authors: Akiko Hata, Koji Yonemoto, Yosuke Shikama, Nanako Aki, Chisato Kosugi, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Masashi Miyoshi, Takayuki Nakao, Makoto Funaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4337907?pdf=render
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spelling doaj-845dcf7e038b4bdc9761ff3915c3e2772020-11-24T21:50:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011837310.1371/journal.pone.0118373Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.Akiko HataKoji YonemotoYosuke ShikamaNanako AkiChisato KosugiAyako TamuraTakako IchiharaTakako MinagawaYumi KuwamuraMasashi MiyoshiTakayuki NakaoMakoto FunakiTo determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS.During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (≤ 4.9, 5.0-6.6, 6.7-8.8 and ≥ 8.9 μg/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02-0.78; P = 0.03) in subjects with total adiponectin level of 5.0-6.6 μg/ml, and 0.15 (95% CI 0.02-0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with those with total adiponectin level ≥ 8.9 μg/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 μg/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml (TR 0.22, 95% CI: 0.08-0.64, P = 0.005).Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 μg/ml in male Japanese workers. Subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 μg/ml.http://europepmc.org/articles/PMC4337907?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Akiko Hata
Koji Yonemoto
Yosuke Shikama
Nanako Aki
Chisato Kosugi
Ayako Tamura
Takako Ichihara
Takako Minagawa
Yumi Kuwamura
Masashi Miyoshi
Takayuki Nakao
Makoto Funaki
spellingShingle Akiko Hata
Koji Yonemoto
Yosuke Shikama
Nanako Aki
Chisato Kosugi
Ayako Tamura
Takako Ichihara
Takako Minagawa
Yumi Kuwamura
Masashi Miyoshi
Takayuki Nakao
Makoto Funaki
Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.
PLoS ONE
author_facet Akiko Hata
Koji Yonemoto
Yosuke Shikama
Nanako Aki
Chisato Kosugi
Ayako Tamura
Takako Ichihara
Takako Minagawa
Yumi Kuwamura
Masashi Miyoshi
Takayuki Nakao
Makoto Funaki
author_sort Akiko Hata
title Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.
title_short Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.
title_full Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.
title_fullStr Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.
title_full_unstemmed Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.
title_sort cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male japanese workers.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2015-01-01
description To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS.During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (≤ 4.9, 5.0-6.6, 6.7-8.8 and ≥ 8.9 μg/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02-0.78; P = 0.03) in subjects with total adiponectin level of 5.0-6.6 μg/ml, and 0.15 (95% CI 0.02-0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with those with total adiponectin level ≥ 8.9 μg/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 μg/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml (TR 0.22, 95% CI: 0.08-0.64, P = 0.005).Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 μg/ml in male Japanese workers. Subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 μg/ml.
url http://europepmc.org/articles/PMC4337907?pdf=render
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