Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.
To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model wa...
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doaj-845dcf7e038b4bdc9761ff3915c3e2772020-11-24T21:50:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011837310.1371/journal.pone.0118373Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.Akiko HataKoji YonemotoYosuke ShikamaNanako AkiChisato KosugiAyako TamuraTakako IchiharaTakako MinagawaYumi KuwamuraMasashi MiyoshiTakayuki NakaoMakoto FunakiTo determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS.During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (≤ 4.9, 5.0-6.6, 6.7-8.8 and ≥ 8.9 μg/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02-0.78; P = 0.03) in subjects with total adiponectin level of 5.0-6.6 μg/ml, and 0.15 (95% CI 0.02-0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with those with total adiponectin level ≥ 8.9 μg/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 μg/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml (TR 0.22, 95% CI: 0.08-0.64, P = 0.005).Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 μg/ml in male Japanese workers. Subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 μg/ml.http://europepmc.org/articles/PMC4337907?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akiko Hata Koji Yonemoto Yosuke Shikama Nanako Aki Chisato Kosugi Ayako Tamura Takako Ichihara Takako Minagawa Yumi Kuwamura Masashi Miyoshi Takayuki Nakao Makoto Funaki |
spellingShingle |
Akiko Hata Koji Yonemoto Yosuke Shikama Nanako Aki Chisato Kosugi Ayako Tamura Takako Ichihara Takako Minagawa Yumi Kuwamura Masashi Miyoshi Takayuki Nakao Makoto Funaki Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers. PLoS ONE |
author_facet |
Akiko Hata Koji Yonemoto Yosuke Shikama Nanako Aki Chisato Kosugi Ayako Tamura Takako Ichihara Takako Minagawa Yumi Kuwamura Masashi Miyoshi Takayuki Nakao Makoto Funaki |
author_sort |
Akiko Hata |
title |
Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers. |
title_short |
Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers. |
title_full |
Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers. |
title_fullStr |
Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers. |
title_full_unstemmed |
Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers. |
title_sort |
cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male japanese workers. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS.During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (≤ 4.9, 5.0-6.6, 6.7-8.8 and ≥ 8.9 μg/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02-0.78; P = 0.03) in subjects with total adiponectin level of 5.0-6.6 μg/ml, and 0.15 (95% CI 0.02-0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with those with total adiponectin level ≥ 8.9 μg/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 μg/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml (TR 0.22, 95% CI: 0.08-0.64, P = 0.005).Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 μg/ml in male Japanese workers. Subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 μg/ml. |
url |
http://europepmc.org/articles/PMC4337907?pdf=render |
work_keys_str_mv |
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