Pro-Inflammatory Th1 and Th17 Cells Are Suppressed During Human Experimental Endotoxemia Whereas Anti-Inflammatory IL-10 Producing T-Cells Are Unaffected

Pro-Inflammatory Th1 and Th17 Cells Are Suppressed During Human Experimental Endotoxemia Whereas Anti-Inflammatory IL-10 Producing T-Cells Are Unaffected

ObjectiveSepsis is one of the leading causes of the deaths in hospitals. During sepsis, patients are exposed to endotoxemia, which may contribute to the dysregulation of the immune system frequently observed in sepsis. This dysregulation leads to impaired pro-inflammatory responses and may increase...

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Bibliographic Details
Main Authors: Alexandra Brinkhoff, Annette Sieberichs, Harald Engler, Sebastian Dolff, Sven Benson, Johannes Korth, Manfred Schedlowski, Andreas Kribben, Oliver Witzke, Benjamin Wilde
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
systemic inflammation
T-cells
IL-17A
IFNγ
Treg
IL-10
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01133/full

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