Effect of Cornus officinalis glycosides on the myelin basic protein in blood serum and the nerve function in Balb/c mice after sciatic nerve injury

• Main Authors: Liang Feng, Wu Suming, Qi Shuang
• Format: Article
• Language: English
• Published: EDP Sciences 2017-01-01
• Series: BIO Web of Conferences
• Online Access: http://dx.doi.org/10.1051/bioconf/20170802012

Objective: to explore the effect of cornus officinalis glycosides(COG) on the myelin basic protein(MBP) in blood serum andthe nerve function in Balb/c mice after sciatic nerve injury. Methods : Adult male Balb/c mice were randomly divided into high-dose, middle-dose, low-dose COG groups,.Transecting and inosculating the right sciatic nerve; testing the concentration of MBP by ELISA in 3, 5 days, 1, 2, 4, 8 weeks and having electroneurophysiological detection in 4, 8 and 12 weeks after surgery respectively; making statistical analysis of the results. Results: The MBP concentration and results of lectroneurophysiological detection have clear dose-effect relationship with the COG dose. Conclusion: Through inhibiting the demyelination of the sciatic nerve , COG can lower the degree of nerve damage so that accelerating the nerve regeneration.