Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment

Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment

The therapeutic efficiency of ascorbate is limited by its slow autoxidation. Here, the authors show the application of concave-structured palladium nanocrystals for the treatment of colorectal cancer through the oxidation of ascorbate, enhancing the production of oxidative stresses specifically on c...

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Main Authors: Yu Chong, Xing Dai, Ge Fang, Renfei Wu, Lin Zhao, Xiaochuan Ma, Xin Tian, Sangyun Lee, Chao Zhang, Chunying Chen, Zhifang Chai, Cuicui Ge, Ruhong Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07257-z
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spelling doaj-845a165ecf944562a8374c43f5a519352021-05-11T10:17:52ZengNature Publishing GroupNature Communications2041-17232018-11-019111010.1038/s41467-018-07257-zPalladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatmentYu Chong0Xing Dai1Ge Fang2Renfei Wu3Lin Zhao4Xiaochuan Ma5Xin Tian6Sangyun Lee7Chao Zhang8Chunying Chen9Zhifang Chai10Cuicui Ge11Ruhong Zhou12State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityComputational Biology Center, IBM Thomas J. Watson Research CenterSchool of Materials Science and Engineering, Anhui University of Science and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, and University of Chinese Academy of SciencesState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityThe therapeutic efficiency of ascorbate is limited by its slow autoxidation. Here, the authors show the application of concave-structured palladium nanocrystals for the treatment of colorectal cancer through the oxidation of ascorbate, enhancing the production of oxidative stresses specifically on cancer cells.https://doi.org/10.1038/s41467-018-07257-z
collection DOAJ
language English
format Article
sources DOAJ
author Yu Chong
Xing Dai
Ge Fang
Renfei Wu
Lin Zhao
Xiaochuan Ma
Xin Tian
Sangyun Lee
Chao Zhang
Chunying Chen
Zhifang Chai
Cuicui Ge
Ruhong Zhou
spellingShingle Yu Chong
Xing Dai
Ge Fang
Renfei Wu
Lin Zhao
Xiaochuan Ma
Xin Tian
Sangyun Lee
Chao Zhang
Chunying Chen
Zhifang Chai
Cuicui Ge
Ruhong Zhou
Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment
Nature Communications
author_facet Yu Chong
Xing Dai
Ge Fang
Renfei Wu
Lin Zhao
Xiaochuan Ma
Xin Tian
Sangyun Lee
Chao Zhang
Chunying Chen
Zhifang Chai
Cuicui Ge
Ruhong Zhou
author_sort Yu Chong
title Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment
title_short Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment
title_full Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment
title_fullStr Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment
title_full_unstemmed Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment
title_sort palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description The therapeutic efficiency of ascorbate is limited by its slow autoxidation. Here, the authors show the application of concave-structured palladium nanocrystals for the treatment of colorectal cancer through the oxidation of ascorbate, enhancing the production of oxidative stresses specifically on cancer cells.
url https://doi.org/10.1038/s41467-018-07257-z
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