Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers

Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers

Over recent years, pigs have been promoted as potential animal model due to their anatomical and physiological similarities with humans. However, information about the contribution of distinct renal elimination processes [glomerular filtration rate (GFR), effective renal plasma flow (ERPF), tubular...

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Bibliographic Details
Main Authors: Laura Dhondt, Siska Croubels, Peter De Paepe, Steven C. Wallis, Saurabh Pandey, Jason A. Roberts, Jeffrey Lipman, Pieter De Cock, Mathias Devreese
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
piglet
renal function
animal model
iohexol
para-aminohippuric acid
pindolol
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00883/full

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