CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B-Cell Acute Lymphocytic Leukemia by Perturbing Cellular Metabolism

CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B-Cell Acute Lymphocytic Leukemia by Perturbing Cellular Metabolism

B-cell acute lymphocytic leukemia (B-ALL) is a malignant blood cancer that develops in children and adults and leads to high mortality. THZ1, a covalent cyclin-dependent kinase 7 (CDK7) inhibitor, shows anti-tumor effects in various cancers by inhibiting cell proliferation and inducing apoptosis. Ho...

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Bibliographic Details
Main Authors: Tuersunayi Abudureheman, Jing Xia, Ming-Hao Li, Hang Zhou, Wei-Wei Zheng, Neng Zhou, Rong-Yi Shi, Jian-Min Zhu, Li-Ting Yang, Li Chen, Liang Zheng, Kai Xue, Kai Qing, Cai-Wen Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
B-cell acute lymphocytic leukemia
CDK7 inhibitor
cell apoptosis
metabolism
c-MYC
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.663360/full

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