Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining

Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining

Shelterin protects chromosome ends from the DNA damage response. Although the mechanism of telomere protection has been studied extensively, the fate of double-strand breaks (DSBs) inside telomeres is not known. Here, we report that telomere-internal FokI-induced DSBs activate ATM kinase-dependent s...

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Bibliographic Details
Main Authors: Ylli Doksani, Titia de Lange
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Subjects:
telomere
end-protection
t-loop
recombination
alt-NHEJ
PARP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313948

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