Increased striatal adenosine A2A receptor levels is an early event in Parkinson’s disease-related pathology and it is potentially regulated by miR-34b

Increased striatal adenosine A2A receptor levels is an early event in Parkinson’s disease-related pathology and it is potentially regulated by miR-34b

Adenosine A2A receptor (A2AR) is a G-protein coupled receptor that stimulates adenylyl cyclase activity. In the brain, A2ARs are found highly enriched in striatal GABAergic medium spiny neurons, related to the control of voluntary movement. Pharmacological modulation of A2ARs is particularly useful...

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Bibliographic Details
Main Authors: Izaskun Villar-Menéndez, Sílvia Porta, Sandra P. Buira, Thais Pereira-Veiga, Sara Díaz-Sánchez, José Luis Albasanz, Isidre Ferrer, Mairena Martín, Marta Barrachina
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Neurobiology of Disease
Subjects:
Adenosine A2A receptor
ADORA2A
miR-34b
Putamen
Parkinson’s disease
Post-mortem
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611400148X

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