Repositioning of Tamoxifen in Surface-Modified Nanocapsules as a Promising Oral Treatment for Visceral Leishmaniasis

Repositioning of Tamoxifen in Surface-Modified Nanocapsules as a Promising Oral Treatment for Visceral Leishmaniasis

Standards of care for human visceral leishmaniasis (VL) are based on drugs used parenterally, and oral treatment options are urgently needed. In the present study, a repurposing strategy was used associating tamoxifen (TMX) with polyethylene glycol-<i>block</i>-polylactide nanocapsules (...

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Bibliographic Details
Main Authors: Débora Faria Silva, Levi Eduardo Soares Reis, Marina Guimarães Carvalho Machado, Douglas Daniel Dophine, Vinicius Roberto de Andrade, Wanderson Geraldo de Lima, Margareth Spangler Andrade, José Mário Carneiro Vilela, Alexandre Barbosa Reis, Gwenaelle Pound-Lana, Simone Aparecida Rezende, Vanessa Carla Furtado Mosqueira
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
tamoxifen
repurposing
leishmaniasis
efficacy
nanocapsule
physicochemical characterization
Online Access:https://www.mdpi.com/1999-4923/13/7/1061

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