Determination of voriconazole and its N-oxide in human plasma by LC-MS/MS and its clinical application

Determination of voriconazole and its N-oxide in human plasma by LC-MS/MS and its clinical application

Objective To develop liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the content determination of voriconazole (VRCZ) and its N-oxide (VNO) in human plasma, and to apply it to clinical samples. Methods Ketoconazole was used as the internal standard (IS). The plasma samples were treated...

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Bibliographic Details
Main Authors:	XIANG Rongfeng, SHANG Shenglan, XIONG Lirong, YU Mingjie, DAI Qing
Format:	Article
Language:	zho
Published:	Editorial Office of Journal of Third Military Medical University 2019-08-01
Series:	Di-san junyi daxue xuebao
Subjects:	voriconazole voriconazole n-oxide lc-ms/ms plasma concentration
Online Access:	http://aammt.tmmu.edu.cn/Upload/rhtml/201902067.htm

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