Determination of voriconazole and its N-oxide in human plasma by LC-MS/MS and its clinical application

Objective To develop liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the content determination of voriconazole (VRCZ) and its N-oxide (VNO) in human plasma, and to apply it to clinical samples. Methods Ketoconazole was used as the internal standard (IS). The plasma samples were treated...

Full description

Bibliographic Details
Main Authors: XIANG Rongfeng, SHANG Shenglan, XIONG Lirong, YU Mingjie, DAI Qing
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2019-08-01
Series:Di-san junyi daxue xuebao
Subjects:
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/201902067.htm