Targeted Inhibition of the miR-199a/214 Cluster by CRISPR Interference Augments the Tumor Tropism of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Hypoxic Condition
The human induced pluripotent stem cell (hiPSC) provides a breakthrough approach that helps overcoming ethical and allergenic challenges posed in application of neural stem cells (NSCs) in targeted cancer gene therapy. However, the tumor-tropic capacity of hiPSC-derived NSCs (hiPS-NSCs) still has mu...
Main Authors: | Yumei Luo, Xuehu Xu, Xiuli An, Xiaofang Sun, Shu Wang, Detu Zhu |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2016-01-01
|
Series: | Stem Cells International |
Online Access: | http://dx.doi.org/10.1155/2016/3598542 |
Similar Items
-
Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference
by: Ashley RG Libby, et al.
Published: (2018-10-01) -
Application of Human Induced Pluripotent Stem Cell-Derived Cellular and Organoid Models for COVID-19 Research
by: Yumei Luo, et al.
Published: (2021-09-01) -
Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
by: Yumei Luo, et al.
Published: (2018-03-01) -
CNS disease models with human pluripotent stem cells in the CRISPR age
by: Muffat, Julien, et al.
Published: (2018) -
An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells
by: Jianying Guo, et al.
Published: (2017-01-01)