Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice.

Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice.

Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether disturbed arginine resynthesis modulates endothelium-dependent vasodilatation in normal and diabetic male mice.Endothelium-selec...

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Bibliographic Details
Main Authors: Ramesh Chennupati, Merlijn J P M T Meens, Vincent Marion, Ben J Janssen, Wouter H Lamers, Jo G R De Mey, S Eleonore Köhler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4102520?pdf=render

Internet

http://europepmc.org/articles/PMC4102520?pdf=render

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