The Diazoxide Derivative 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide Augments AMPA- and GABA-Mediated Synaptic Responses in Cultured Hippocampal Neurons

The Diazoxide Derivative 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide Augments AMPA- and GABA-Mediated Synaptic Responses in Cultured Hippocampal Neurons

The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide (IDRA21) enhances memory and learning in rodents, most likely by potentiating AMPAergic synaptic activity. We examined IDRA21's effect upon AMPAergic synaptic currents and whole-cell glutamate currents...

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Bibliographic Details
Main Authors: Kelvin A. Yamada, Matthew W. Hill, Yuefei Hu, Douglas F. Covey
Format: Article
Language:English
Published: Elsevier 1998-09-01
Series:Neurobiology of Disease
Subjects:
AMPA
cyclothiazide
autapse
excitatory postsynaptic current
benzothiadiazine
thiazide.
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996198901966

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http://www.sciencedirect.com/science/article/pii/S0969996198901966

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