Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice

Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice

Food allergy is a potentially fatal disease affecting 8% of children and has become increasingly common in the past two decades. Despite the prevalence and severe nature of the disease, the mechanisms underlying sensitization remain to be further elucidated. The Collaborative Cross is a genetically...

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Bibliographic Details
Main Authors: Johanna M. Smeekens, Brandi T. Johnson-Weaver, Andrew L. Hinton, M. Andrea Azcarate-Peril, Timothy P. Moran, Robert M. Immormino, Janelle R. Kesselring, Erin C. Steinbach, Kelly A. Orgel, Herman F. Staats, A. Wesley Burks, Peter J. Mucha, Martin T. Ferris, Michael D. Kulis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
food allergy
peanut allergy
IgE
microbiome
Tfh cells
fecal IgA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.599637/full

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