Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.
Hepatic circadian gene transcription is tightly coupled to feeding behavior, which has a profound impact on metabolic disorders associated with diet-induced obesity. Here, we describe a genomics approach to uncover mechanisms controlling hepatic postprandial gene expression. Combined transcriptomic...
Main Authors: | Adrija Kalvisa, Majken S Siersbæk, Stine M Præstholm, Line J L Christensen, Ronni Nielsen, Oliver Stohr, Sabine Vettorazzi, Jan Tuckermann, Morris White, Susanne Mandrup, Lars Grøntved |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-12-01
|
Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.2006249 |
Similar Items
-
Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone.
by: Stine M Præstholm, et al.
Published: (2020-05-01) -
Multifaceted Control of GR Signaling and Its Impact on Hepatic Transcriptional Networks and Metabolism
by: Stine M. Præstholm, et al.
Published: (2020-10-01) -
Molecular mechanisms of the glucocorticoid receptor in steroid therapy – lessons from transgenic mice
by: Hübner Sabine, et al.
Published: (2012-06-01) -
Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor
by: Laura Escoter-Torres, et al.
Published: (2019-08-01) -
Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation
by: Martin Wepler, et al.
Published: (2020-12-01)