Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives
Coxsackievirus B3 (CVB3) is the most common cause of acute and chronic viral myocarditis, primarily in children, while human adenovirus infections represent a significant cause of morbidity and mortality worldwide, in people of all ages. A series of novel 2-benzoxyl-phenylpyridine derivatives were e...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/6/1409 |
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doaj-841b1bd938cb4588b361712153d86ce8 |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yanhong Wei Haijie Wang Caili Xi Ni Li Dong Li Chenguang Yao Ge Sun Hongmei Ge Kanghong Hu Qian Zhang |
| spellingShingle |
Yanhong Wei Haijie Wang Caili Xi Ni Li Dong Li Chenguang Yao Ge Sun Hongmei Ge Kanghong Hu Qian Zhang Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives Molecules 2-benzoxyl-phenylpyridine derivatives antiviral activity cvb3 adv7 |
| author_facet |
Yanhong Wei Haijie Wang Caili Xi Ni Li Dong Li Chenguang Yao Ge Sun Hongmei Ge Kanghong Hu Qian Zhang |
| author_sort |
Yanhong Wei |
| title |
Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives |
| title_short |
Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives |
| title_full |
Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives |
| title_fullStr |
Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives |
| title_full_unstemmed |
Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives |
| title_sort |
antiviral effects of novel 2-benzoxyl-phenylpyridine derivatives |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2020-03-01 |
| description |
Coxsackievirus B3 (CVB3) is the most common cause of acute and chronic viral myocarditis, primarily in children, while human adenovirus infections represent a significant cause of morbidity and mortality worldwide, in people of all ages. A series of novel 2-benzoxyl-phenylpyridine derivatives were evaluated for their potential antiviral activities against CVB3 and adenovirus type 7 (ADV7). Preliminary assays indicated that some of these compounds exhibited excellent antiviral effects on both CVB3 and ADV7 viruses; they could effectively inhibit virus-induced cytopathic effects, reduce viral progeny yields, and had similar or superior antiviral activities compared with the control drug, ribavirin. Further, these compounds targeted the early stages of CVB3 replication in cells, including viral RNA replication and protein synthesis, rather than inactivating the virus directly, inhibiting virus adsorption/entry, or affecting viral release from cells. Our data demonstrate that the tested 2-benzoxyl-phenylpyridine derivatives are effective inhibitors of CVB3 and ADV7, raising the possibility that these compounds might be feasible candidates for anti-viral agents. |
| topic |
2-benzoxyl-phenylpyridine derivatives antiviral activity cvb3 adv7 |
| url |
https://www.mdpi.com/1420-3049/25/6/1409 |
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doaj-841b1bd938cb4588b361712153d86ce82020-11-25T03:10:06ZengMDPI AGMolecules1420-30492020-03-01256140910.3390/molecules25061409molecules25061409Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine DerivativesYanhong Wei0Haijie Wang1Caili Xi2Ni Li3Dong Li4Chenguang Yao5Ge Sun6Hongmei Ge7Kanghong Hu8Qian Zhang9National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaSchool of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaSchool of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, ChinaCoxsackievirus B3 (CVB3) is the most common cause of acute and chronic viral myocarditis, primarily in children, while human adenovirus infections represent a significant cause of morbidity and mortality worldwide, in people of all ages. A series of novel 2-benzoxyl-phenylpyridine derivatives were evaluated for their potential antiviral activities against CVB3 and adenovirus type 7 (ADV7). Preliminary assays indicated that some of these compounds exhibited excellent antiviral effects on both CVB3 and ADV7 viruses; they could effectively inhibit virus-induced cytopathic effects, reduce viral progeny yields, and had similar or superior antiviral activities compared with the control drug, ribavirin. Further, these compounds targeted the early stages of CVB3 replication in cells, including viral RNA replication and protein synthesis, rather than inactivating the virus directly, inhibiting virus adsorption/entry, or affecting viral release from cells. Our data demonstrate that the tested 2-benzoxyl-phenylpyridine derivatives are effective inhibitors of CVB3 and ADV7, raising the possibility that these compounds might be feasible candidates for anti-viral agents.https://www.mdpi.com/1420-3049/25/6/14092-benzoxyl-phenylpyridine derivativesantiviral activitycvb3adv7 |