Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention

Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention

Management of patients on long-term anticoagulation requiring percutaneous coronary intervention is challenging. Triple therapy with oral anticoagulant and dual antiplatelet therapy is the standard of care. However, there is no strong evidence to support this strategy. There is emerging data regardi...

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Main Authors: Nayan Agarwal, Dhruv Mahtta, Cecil A. Rambarat, Islam Elgendy, Ahmed N. Mahmoud
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/5690640
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spelling doaj-841a1233467044898c344b9de8845ebe2020-11-24T21:30:39ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/56906405690640Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary InterventionNayan Agarwal0Dhruv Mahtta1Cecil A. Rambarat2Islam Elgendy3Ahmed N. Mahmoud4Department of Medicine, University of Florida, Gainesville, FL, USADepartment of Medicine, University of Florida, Gainesville, FL, USADepartment of Medicine, University of Florida, Gainesville, FL, USADepartment of Medicine, University of Florida, Gainesville, FL, USADepartment of Medicine, University of Florida, Gainesville, FL, USAManagement of patients on long-term anticoagulation requiring percutaneous coronary intervention is challenging. Triple therapy with oral anticoagulant and dual antiplatelet therapy is the standard of care. However, there is no strong evidence to support this strategy. There is emerging data regarding the safety and efficacy of dual therapy with oral anticoagulant and single antiplatelet therapy in these patients. In this comprehensive review we highlight available evidence regarding various antithrombotic regimens’ efficacy and safety in patient with coronary artery disease undergoing percutaneous coronary intervention with long-term anticoagulation therapy requirements.http://dx.doi.org/10.1155/2018/5690640
collection DOAJ
language English
format Article
sources DOAJ
author Nayan Agarwal
Dhruv Mahtta
Cecil A. Rambarat
Islam Elgendy
Ahmed N. Mahmoud
spellingShingle Nayan Agarwal
Dhruv Mahtta
Cecil A. Rambarat
Islam Elgendy
Ahmed N. Mahmoud
Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention
BioMed Research International
author_facet Nayan Agarwal
Dhruv Mahtta
Cecil A. Rambarat
Islam Elgendy
Ahmed N. Mahmoud
author_sort Nayan Agarwal
title Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention
title_short Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention
title_full Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention
title_fullStr Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention
title_full_unstemmed Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention
title_sort optimum antithrombotic therapy in patients requiring long-term anticoagulation and undergoing percutaneous coronary intervention
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2018-01-01
description Management of patients on long-term anticoagulation requiring percutaneous coronary intervention is challenging. Triple therapy with oral anticoagulant and dual antiplatelet therapy is the standard of care. However, there is no strong evidence to support this strategy. There is emerging data regarding the safety and efficacy of dual therapy with oral anticoagulant and single antiplatelet therapy in these patients. In this comprehensive review we highlight available evidence regarding various antithrombotic regimens’ efficacy and safety in patient with coronary artery disease undergoing percutaneous coronary intervention with long-term anticoagulation therapy requirements.
url http://dx.doi.org/10.1155/2018/5690640
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