Age-related changes in the global DNA methylation profile of leukocytes are linked to nutrition but are not associated with the MTHFR C677T genotype or to functional capacities.

Age-related changes in the global DNA methylation profile of leukocytes are linked to nutrition but are not associated with the MTHFR C677T genotype or to functional capacities.

Global DNA methylation of peripheral blood leukocytes has been recently proposed as a potential biomarker for disease risk. However, the amplitude of the changes in DNA methylation associated with normal aging and the impacts of environmental changes on this variation are still unclear. In this cont...

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Bibliographic Details
Main Authors: Marcus V M Gomes, Leandro V Toffoli, Douglas W Arruda, Larissa M Soldera, Gislaine G Pelosi, Rejane D Neves-Souza, Eliane R Freitas, Denilson T Castro, Audrey S Marquez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527598?pdf=render

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