Leptin alters energy intake and fat mass but not energy expenditure in lean subjects

Leptin alters energy intake and fat mass but not energy expenditure in lean subjects

Leptin treatment is effective to reduce body weight in animal models, but patients with obesity and associated hyperleptinemia do not respond well to leptin therapy. Here the authors report a retrospective analysis of four clinical trials in normo- and mildly hypoleptinemic individuals and show that...

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Main Authors: Pavlina Chrysafi, Nikolaos Perakakis, Olivia M. Farr, Konstantinos Stefanakis, Natia Peradze, Aleix Sala-Vila, Christos S. Mantzoros
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18885-9
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spelling doaj-84158d742bc143a7890d54e03f2e13a82021-05-11T08:35:43ZengNature Publishing GroupNature Communications2041-17232020-10-0111111510.1038/s41467-020-18885-9Leptin alters energy intake and fat mass but not energy expenditure in lean subjectsPavlina Chrysafi0Nikolaos Perakakis1Olivia M. Farr2Konstantinos Stefanakis3Natia Peradze4Aleix Sala-Vila5Christos S. Mantzoros6Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolBarcelonaβeta Brain Research Center, Pasqual Maragall FoundationDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolLeptin treatment is effective to reduce body weight in animal models, but patients with obesity and associated hyperleptinemia do not respond well to leptin therapy. Here the authors report a retrospective analysis of four clinical trials in normo- and mildly hypoleptinemic individuals and show that leptin therapy alters food intake in the short term and reduces weight and fat mass in the long term without effects on energy expenditure.https://doi.org/10.1038/s41467-020-18885-9
collection DOAJ
language English
format Article
sources DOAJ
author Pavlina Chrysafi
Nikolaos Perakakis
Olivia M. Farr
Konstantinos Stefanakis
Natia Peradze
Aleix Sala-Vila
Christos S. Mantzoros
spellingShingle Pavlina Chrysafi
Nikolaos Perakakis
Olivia M. Farr
Konstantinos Stefanakis
Natia Peradze
Aleix Sala-Vila
Christos S. Mantzoros
Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
Nature Communications
author_facet Pavlina Chrysafi
Nikolaos Perakakis
Olivia M. Farr
Konstantinos Stefanakis
Natia Peradze
Aleix Sala-Vila
Christos S. Mantzoros
author_sort Pavlina Chrysafi
title Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
title_short Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
title_full Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
title_fullStr Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
title_full_unstemmed Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
title_sort leptin alters energy intake and fat mass but not energy expenditure in lean subjects
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description Leptin treatment is effective to reduce body weight in animal models, but patients with obesity and associated hyperleptinemia do not respond well to leptin therapy. Here the authors report a retrospective analysis of four clinical trials in normo- and mildly hypoleptinemic individuals and show that leptin therapy alters food intake in the short term and reduces weight and fat mass in the long term without effects on energy expenditure.
url https://doi.org/10.1038/s41467-020-18885-9
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