Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli

Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli

The proton motive force (PMF) is a critical electrochemical gradient involved in bacterial energy metabolism. Here, Miaomiao Wang, Edward Wai Chi Chan et al. demonstrate that the PMF plays a key role in starvation-induced antibiotic tolerance in E. coli, suggesting that PMF disruption could be a fut...

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Main Authors: Miaomiao Wang, Edward Wai Chi Chan, Yingkun Wan, Marcus Ho-yin Wong, Sheng Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02612-1
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spelling doaj-8414b54986c941f29ad265435e8464422021-09-19T11:15:18ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111110.1038/s42003-021-02612-1Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coliMiaomiao Wang0Edward Wai Chi Chan1Yingkun Wan2Marcus Ho-yin Wong3Sheng Chen4State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic UniversityState Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic UniversityDepartment of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong KongState Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic UniversityDepartment of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong KongThe proton motive force (PMF) is a critical electrochemical gradient involved in bacterial energy metabolism. Here, Miaomiao Wang, Edward Wai Chi Chan et al. demonstrate that the PMF plays a key role in starvation-induced antibiotic tolerance in E. coli, suggesting that PMF disruption could be a future strategy to treat bacterial infection.https://doi.org/10.1038/s42003-021-02612-1
collection DOAJ
language English
format Article
sources DOAJ
author Miaomiao Wang
Edward Wai Chi Chan
Yingkun Wan
Marcus Ho-yin Wong
Sheng Chen
spellingShingle Miaomiao Wang
Edward Wai Chi Chan
Yingkun Wan
Marcus Ho-yin Wong
Sheng Chen
Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli
Communications Biology
author_facet Miaomiao Wang
Edward Wai Chi Chan
Yingkun Wan
Marcus Ho-yin Wong
Sheng Chen
author_sort Miaomiao Wang
title Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli
title_short Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli
title_full Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli
title_fullStr Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli
title_full_unstemmed Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli
title_sort active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in escherichia coli
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-09-01
description The proton motive force (PMF) is a critical electrochemical gradient involved in bacterial energy metabolism. Here, Miaomiao Wang, Edward Wai Chi Chan et al. demonstrate that the PMF plays a key role in starvation-induced antibiotic tolerance in E. coli, suggesting that PMF disruption could be a future strategy to treat bacterial infection.
url https://doi.org/10.1038/s42003-021-02612-1
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AT yingkunwan activemaintenanceofprotonmotiveforcemediatesstarvationinducedbacterialantibiotictoleranceinescherichiacoli
AT marcushoyinwong activemaintenanceofprotonmotiveforcemediatesstarvationinducedbacterialantibiotictoleranceinescherichiacoli
AT shengchen activemaintenanceofprotonmotiveforcemediatesstarvationinducedbacterialantibiotictoleranceinescherichiacoli
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