| Summary: | Background: Uncooperative children require sedative approach for dental treatment. The aim was to assess the effectiveness of Propofol in “Non-Operating Room Anesthesia” (NORA) for paediatric dental treatment; intraoperative side effects; postoperative side effects; post-discharge effects. Methods: a prospective study, involving 109 uncooperative children undergoing sedation in NORA using Propofol for dental treatment, was performed. Working sessions, success/failure, intraoperative and postoperative side effects, number of treatment; type of procedure were assessed. Parents completed a post-discharge questionnaire on: pain; crying; fever; vomiting; headache; drowsiness; excitability; irritability; ability to eat; drugs and medical care needing. Results: Success: 96.7%. Intraoperative side effects: 33.3%. Postoperative side effects: 6.4%. Statistically significant association between: intraoperative side effects and age (<i>p</i> = 0.001), health status (<i>p</i> = 0.0007), weight (<i>p</i> = 0.038), respectively; intraoperative side effects and number/ type of dental treatment (<i>p</i> = 0.0055) and scaling (<i>p</i> = 0.0001), respectively. For post-discharge questionnaires, statistically significant association between: age and crying (<i>p</i> = 0.0001) and headache (<i>p</i> = 0.002), respectively; health status and crying (<i>p</i> = 0.015) and drugs needing (<i>p</i> = 0.04), respectively; weight and crying (<i>p</i> = 0.0004); extraction and pain (<i>p</i> = 0.0001) and crying (<i>p</i>= 0.0073), respectively; scaling and crying (<i>p</i> = 0.04), excitability and irritability (<i>p</i> = 0.03), respectively. Conclusion: Propofol in NORA was effective with minimal side effects.
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