The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.

The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.

To elicit effective invasion and egress from infected cells, obligate intracellular parasites of the phylum Apicomplexa rely on the timely and spatially controlled exocytosis of specialized secretory organelles termed the micronemes. The effector molecules and signaling events underpinning this proc...

Full description

Bibliographic Details
Main Authors: Hayley E Bullen, Hugo Bisio, Dominique Soldati-Favre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007670
id doaj-840d598b7d5247ea817f67071eebc6c2
record_format Article
spelling doaj-840d598b7d5247ea817f67071eebc6c22021-04-21T17:10:46ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742019-05-01155e100767010.1371/journal.ppat.1007670The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.Hayley E BullenHugo BisioDominique Soldati-FavreTo elicit effective invasion and egress from infected cells, obligate intracellular parasites of the phylum Apicomplexa rely on the timely and spatially controlled exocytosis of specialized secretory organelles termed the micronemes. The effector molecules and signaling events underpinning this process are intricate; however, recent advances within the field of Toxoplasma gondii research have facilitated a broader understanding as well as a more integrated view of this complex cascade of events and have unraveled the importance of phosphatidic acid (PA) as a lipid mediator at multiple steps in this process.https://doi.org/10.1371/journal.ppat.1007670
collection DOAJ
language English
format Article
sources DOAJ
author Hayley E Bullen
Hugo Bisio
Dominique Soldati-Favre
spellingShingle Hayley E Bullen
Hugo Bisio
Dominique Soldati-Favre
The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.
PLoS Pathogens
author_facet Hayley E Bullen
Hugo Bisio
Dominique Soldati-Favre
author_sort Hayley E Bullen
title The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.
title_short The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.
title_full The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.
title_fullStr The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.
title_full_unstemmed The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.
title_sort triumvirate of signaling molecules controlling toxoplasma microneme exocytosis: cyclic gmp, calcium, and phosphatidic acid.
publisher Public Library of Science (PLoS)
series PLoS Pathogens
issn 1553-7366
1553-7374
publishDate 2019-05-01
description To elicit effective invasion and egress from infected cells, obligate intracellular parasites of the phylum Apicomplexa rely on the timely and spatially controlled exocytosis of specialized secretory organelles termed the micronemes. The effector molecules and signaling events underpinning this process are intricate; however, recent advances within the field of Toxoplasma gondii research have facilitated a broader understanding as well as a more integrated view of this complex cascade of events and have unraveled the importance of phosphatidic acid (PA) as a lipid mediator at multiple steps in this process.
url https://doi.org/10.1371/journal.ppat.1007670
work_keys_str_mv AT hayleyebullen thetriumvirateofsignalingmoleculescontrollingtoxoplasmamicronemeexocytosiscyclicgmpcalciumandphosphatidicacid
AT hugobisio thetriumvirateofsignalingmoleculescontrollingtoxoplasmamicronemeexocytosiscyclicgmpcalciumandphosphatidicacid
AT dominiquesoldatifavre thetriumvirateofsignalingmoleculescontrollingtoxoplasmamicronemeexocytosiscyclicgmpcalciumandphosphatidicacid
AT hayleyebullen triumvirateofsignalingmoleculescontrollingtoxoplasmamicronemeexocytosiscyclicgmpcalciumandphosphatidicacid
AT hugobisio triumvirateofsignalingmoleculescontrollingtoxoplasmamicronemeexocytosiscyclicgmpcalciumandphosphatidicacid
AT dominiquesoldatifavre triumvirateofsignalingmoleculescontrollingtoxoplasmamicronemeexocytosiscyclicgmpcalciumandphosphatidicacid
_version_ 1714666506151788544

Similar Items