Construction of GPR183 knockout mice and its function in acute liver injury

Construction of GPR183 knockout mice and its function in acute liver injury

Objective To construct a GPR183 knockout mouse model by genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system, and to analyze the role of GPR183 receptor in lymphocyte regulation and acute liver injury. Methods Firstly, GPR1...

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Bibliographic Details
Main Authors: WU Xuewen, YIN Siqi, QIAN Ying, DU Bing, QIN Juliang, CHEN Jinlian
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2021-09-01
Series:Di-san junyi daxue xuebao
Subjects:
crispr/cas9 gene editing technology
g protein coupled receptor
gene knockout
acute liver injury
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/202103181.htm

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