A diffusion approximation and numerical methods for adaptive neuron models with stochastic inputs

• Main Author: Robert eRosenbaum
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2016-04-01
• Series: Frontiers in Computational Neuroscience
• Subjects: Spike frequency adaptation; Numerical Analysis; Stochastic Modeling; diffusion approximation; Fokker-Planck equation; linear response
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fncom.2016.00039/full

Characterizing the spiking statistics of neurons receiving noisy synaptic input is a central problem in computational neuroscience. Monte Carlo approaches to this problem are computationally expensive and often fail to provide mechanistic insight. Thus, the field has seen the development of mathematical and numerical approaches, often relying on a Fokker-Planck formalism. These approaches force a compromise between biological realism, accuracy and computational efficiency. In this article we develop an extension of existing diffusion approximations to more accurately approximate the response of neurons with adaptation currents and noisy synaptic currents. The implementation refines existing numerical schemes for solving the associated Fokker-Planck equations to improve computationally efficiency and accuracy. Computer code implementing the developed algorithms is made available to the public.