Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination
Demyelination results in impairments in oligodendrocyte progenitor cell recruitment. Here the authors identify sulfatase 1/2 as a potential modulator of myelination by modulating the microenvironment around oligodendrocyte progenitor cells.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22263-4 |
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doaj-8405f74419104281af9993328f364b192021-03-28T11:12:06ZengNature Publishing GroupNature Communications2041-17232021-03-0112111810.1038/s41467-021-22263-4Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelinationDarpan Saraswat0Hani J. Shayya1Jessie J. Polanco2Ajai Tripathi3R. Ross Welliver4Suyog U. Pol5Richard A. Seidman6Jacqueline E. Broome7Melanie A. O’Bara8Toin H. van Kuppervelt9Joanna J. Phillips10Ranjan Dutta11Fraser J. Sim12Department of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at BuffaloNeuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Neuroscience, Lerner Research InstituteNeuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at BuffaloNeuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical CenterDepartment of Neurological Surgery, University of CaliforniaDepartment of Neuroscience, Lerner Research InstituteDepartment of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at BuffaloDemyelination results in impairments in oligodendrocyte progenitor cell recruitment. Here the authors identify sulfatase 1/2 as a potential modulator of myelination by modulating the microenvironment around oligodendrocyte progenitor cells.https://doi.org/10.1038/s41467-021-22263-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Darpan Saraswat Hani J. Shayya Jessie J. Polanco Ajai Tripathi R. Ross Welliver Suyog U. Pol Richard A. Seidman Jacqueline E. Broome Melanie A. O’Bara Toin H. van Kuppervelt Joanna J. Phillips Ranjan Dutta Fraser J. Sim |
| spellingShingle |
Darpan Saraswat Hani J. Shayya Jessie J. Polanco Ajai Tripathi R. Ross Welliver Suyog U. Pol Richard A. Seidman Jacqueline E. Broome Melanie A. O’Bara Toin H. van Kuppervelt Joanna J. Phillips Ranjan Dutta Fraser J. Sim Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination Nature Communications |
| author_facet |
Darpan Saraswat Hani J. Shayya Jessie J. Polanco Ajai Tripathi R. Ross Welliver Suyog U. Pol Richard A. Seidman Jacqueline E. Broome Melanie A. O’Bara Toin H. van Kuppervelt Joanna J. Phillips Ranjan Dutta Fraser J. Sim |
| author_sort |
Darpan Saraswat |
| title |
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination |
| title_short |
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination |
| title_full |
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination |
| title_fullStr |
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination |
| title_full_unstemmed |
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination |
| title_sort |
overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
Demyelination results in impairments in oligodendrocyte progenitor cell recruitment. Here the authors identify sulfatase 1/2 as a potential modulator of myelination by modulating the microenvironment around oligodendrocyte progenitor cells. |
| url |
https://doi.org/10.1038/s41467-021-22263-4 |
| work_keys_str_mv |
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