Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

<p>Abstract</p> <p>Background</p> <p>Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies could reflect the disru...

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Bibliographic Details
Main Authors: Torres Manuel, Jimenez Sebastian, Sanchez-Varo Raquel, Navarro Victoria, Trujillo-Estrada Laura, Sanchez-Mejias Elisabeth, Carmona Irene, Davila Jose Carlos, Vizuete Marisa, Gutierrez Antonia, Vitorica Javier
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
PS1/APP transgenic model
Dystrophic neurites
Tau phosphorylation. Cathepsin activity
APP processing
Abeta production
Online Access:http://www.molecularneurodegeneration.com/content/7/1/59

Internet

http://www.molecularneurodegeneration.com/content/7/1/59

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