<b>Phloroglucinol derivatives and flavones from <i>Helichrysum paronychioides</i></b>

<b>Phloroglucinol derivatives and flavones from <i>Helichrysum paronychioides</i></b>

Investigation of <i>Helichrysum paronychioides</i> afforded a total of nine compounds: 4 phloroglucinol derivatives, 2 of which are novel natural products, and 5 flavone derivatives. Structures were established by various spectroscopic techniques (NMR, MS, UV, IR, CD) and by comparison w...

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Bibliographic Details
Main Authors: J. Mutanyatta-Comar, O.J.K. Phale, B.M. Abegaz, K. Croft
Format: Article
Language:English
Published: Chemical Society of Ethiopia 2006-06-01
Series:Bulletin of the Chemical Society of Ethiopia
Subjects:
<i>Helichrysum paronychioides</i>
Asteraceae
Phloroglucinol derivatives
CD spectroscopy
Synthesis
Online Access:http://www.ajol.info/index.php/bcse/article/view/21144
Description
Summary:Investigation of <i>Helichrysum paronychioides</i> afforded a total of nine compounds: 4 phloroglucinol derivatives, 2 of which are novel natural products, and 5 flavone derivatives. Structures were established by various spectroscopic techniques (NMR, MS, UV, IR, CD) and by comparison with literature data for the known compounds. The four phloroglucinols, trans-(2<i>R</i>,3<i>R</i>)-5,7-dihydroxy-2,3-dimethyl-4-chromanone (<b>1</b>), 2-butanoyl-4-prenyl-1-methoxy phloroglucinol (<b>2</b>), 2-(2-methylpropanoyl)-4-prenylphloroglucinol (<b>3</b>) and 2-(2-methyl- butanoyl)-4-prenylphloroglucinol (<b>4</b>) were screened for antioxidant activity against Cu-induced LDL oxidation. Compound <b>4</b> was found to be the most active inhibiting LDL oxidation at all concentrations (0.5-10 μM) while the other three showed moderate to no activity.
ISSN:1011-3924
1726-801X

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