A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway

A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway

Abstract Background Targeting the c-Met signaling pathway has become a therapeutic strategy in multiple types of cancer. We unveiled a novel c-Met regulating mechanism that could be applied as a modality for oral squamous cell carcinoma (OSCC) therapy. Methods Upregulation of keratin 16 (KRT16) was...

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Bibliographic Details
Main Authors: Wei-Chieh Huang, Te-Hsuan Jang, Shiao-Lin Tung, Tzu-Chen Yen, Shih-Hsuan Chan, Lu-Hai Wang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Oral squamous cell carcinoma
miR-365-3p
Keratin 16
C-met
ETS homologous factor
β5-integrin
Online Access:http://link.springer.com/article/10.1186/s13046-019-1091-5

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