Dieckol Ameliorates Aβ Production via PI3K<i>/</i>Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell

Dieckol Ameliorates Aβ Production via PI3K<i>/</i>Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell

The proteolytic processing of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase releases amyloid-β peptide (Aβ), which deposits in amyloid plaques and contributes to the initial causative events of Alzheimer’s disease (AD). In the present study, the regulatory mechanism of APP p...

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Bibliographic Details
Main Authors: Jeong-Hyun Yoon, Nayoung Lee, Kumju Youn, Mi Ra Jo, Hyeung-Rak Kim, Dong-Seok Lee, Chi-Tang Ho, Mira Jun
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Marine Drugs
Subjects:
Alzheimer’s disease
amyloid-beta peptide
GSK-3β
dieckol
SweAPP N2a
Online Access:https://www.mdpi.com/1660-3397/19/3/152

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