Hermetically Packaged Microsensor for Quality Factor-Enhanced Photoacoustic Biosensing
The use of photoacoustics (PA) being a convenient non-invasive analysis tool is widespread in various biomedical fields. Despite significant advances in traditional PA cell systems, detection platforms capable of providing high signal-to-noise ratios and steady operation are yet to be developed for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-06-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221359792030029X |
| Summary: | The use of photoacoustics (PA) being a convenient non-invasive analysis tool is widespread in various biomedical fields. Despite significant advances in traditional PA cell systems, detection platforms capable of providing high signal-to-noise ratios and steady operation are yet to be developed for practical micro/nano biosensing applications. Microfabricated transducers offer orders of magnitude higher quality factors and greatly enhanced performance in extremely miniature dimensions that is unattainable with large-scale PA cells. In this work we exploit these attractive attributes of microfabrication technology and describe the first implementation of a vacuum-packaged microscale resonator in photoacoustic biosensing. Steady operation of this functional approach is demonstrated by detecting the minuscule PA signals from the variations of trace amounts of glucose in gelatin-based synthetic tissues. These results demonstrate the potential of the novel approach to broad photoacoustic applications, spanning from micro-biosensing modules to the analysis of solid and liquid analytes of interest in condense mediums. |
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| ISSN: | 2213-5979 |