COMPARISON OF SERUM LEVELS OF CRP AND URIC ACID IN ACTIVE, PASSIVE, AND NON-SMOKERS

• Main Authors: Maryam Boshtam, Mahboobeh Abbaszadeh, Morteza Rafiei, Mansoor Shahparian, Mohsen Boshtam
• Format: Article
• Language: English
• Published: Vesnu Publications 2010-12-01
• Series: ARYA Atherosclerosis
• Online Access: http://arya.mui.ac.ir/index.php/arya/article/view/127

Abstract<br />INTRODUCTION: Some studies have shown that C-reactive protein (CRP) and uric<br />acid may have a role in development of coronary artery disease (CAD); the role cigarette<br />smoking plays in CAD through various mechanisms has also been demonstrated. Hence,<br />the question is raised: does cigarette smoking exert its atherogenic effect through<br />increasing CRP and uric acid levels in the serum? The first step in responding to this<br />question would be to study the relationship between cigarette smoking, CAD, CRP and<br />uric acid levels. As cigarette smoking is highly prevalent in Iran, the present study was<br />conducted to compare mean serum levels of CRP and uric acid in 3 groups of active<br />smokers, passive smokers, and non-smokers, to determine any possible association<br />between cigarette smoking and serum CRP and uric acid levels.<br />METHODS: The study involved 177 men aged 20-40 years in 3 groups of active<br />smokers, passive smokers, and non-smokers (59 individuals in each group). In addition,<br />fasting blood samples were taken from all subjects to measure serum levels of CRP<br />serologically and uric acid photometrically (using ELAN 2000). Questionnaires on<br />anthropometrics, personal information, disease history, drug use and other related<br />subjects were completed for all the subjects.<br />RESULTS: Mean serum CRP levels were 5.4