Semi-automated Modular Program Constructor for physiological modeling: Building cell and organ models [version 3; referees: 2 approved]

• Main Authors: Bartholomew Jardine, Gary M. Raymond, James B. Bassingthwaighte
• Format: Article
• Language: English
• Published: F1000 Research Ltd 2016-06-01
• Series: F1000Research
• Subjects: Bioinformatics; Theory & Simulation
• Online Access: http://f1000research.com/articles/4-1461/v3

The Modular Program Constructor (MPC) is an open-source Java based modeling utility, built upon JSim's Mathematical Modeling Language (MML) ( http://www.physiome.org/jsim/) that uses directives embedded in model code to construct larger, more complicated models quickly and with less error than manually combining models. A major obstacle in writing complex models for physiological processes is the large amount of time it takes to model the myriad processes taking place simultaneously in cells, tissues, and organs. MPC replaces this task with code-generating algorithms that take model code from several different existing models and produce model code for a new JSim model. This is particularly useful during multi-scale model development where many variants are to be configured and tested against data. MPC encodes and preserves information about how a model is built from its simpler model modules, allowing the researcher to quickly substitute or update modules for hypothesis testing. MPC is implemented in Java and requires JSim to use its output. MPC source code and documentation are available at http://www.physiome.org/software/MPC/.